产品说明
一般描述
FST (follistatin) is an activin-binding protein, and exists in two isoforms due to alternate splicing, FS288 and FS315. It is a glycoprotein with a single chain, and acts as an activin antagonist. It has a high level of expression in fetal membranes and placenta.
包装
25 μg in glass insert
生化/生理作用
FST (follistatin) binds to and regulates activins, which in turn are TGF (transforming growth factor)-β superfamily members. The expression level of FST and its binding partner activin A is elevated in inflammatory disorders. The activin A-follistatin system plays an essential role in the modulation of glucose and lipid metabolism, which might have an overall effect on fetal growth. In adipose tissue, it facilitates the adipogenic differentiation of progenitor cells.
High affinity activin-binding protein that can act as an activin antagonist.
外形
Recombinant Mouse Follistatin 288 is supplied as a approximately 25 μg of protein lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA containing 1.25 mg of bovine serum albumin.
分析说明
The biological activity is measured by its ability to neutralize activin-induced erythroid differentiation on K562 cells.
基本信息
| MDL编号 | MFCD03456879 |
| NACRES | NA.32 |
产品性质
| 质量水平 | 100 |
| 生物来源 | mouse |
| 重组 | expressed in baculovirus infected Sf21 cells |
| 测定 | >95% (SDS-PAGE) |
| 形式 | lyophilized powder |
| 效能 | 0.04-0.4 mg per mL |
| 分子量 | calculated mol wt ~31 kDa |
| 包装 | pkg of 25 μg |
| 储存条件 | avoid repeated freeze/thaw cycles |
| 杂质 | endotoxin, tested |
| UniProt登记号 | P47931 |
| 储存温度 | −20℃ |
| Gene Information | mouse ... Fst(14313) |
安全信息
| 象形图 |  |
| 警示用语： | Danger |
| 危险声明 | H315 - H318 |
| 预防措施声明 | P280 - P305 + P351 + P338 + P310 |
| 危险分类 | Eye Dam. 1 - Skin Irrit. 2 |
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
