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Anti-SH3GL1 antibody produced in chicken

品牌
Sigma-Aldrich
货号
GW22560F
规格纯度
affinity isolated antibody, buffered aqueous solution
参考价格
4692 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-SH3GL1 antibody produced in chicken
产品介绍:

产品说明

一般描述

SH3GL1 (SH3-domain GRB2-like 1), also called EA2 (endophilin A2), was initially recognized as a fusion partner of MLL (mixed-lineage leukaemia) translocation in childhood leukaemia. It is the first member of the EEN/EA SH3 domain (Src homology 3 domain)-containing family of proteins. It is found in the cells of haemopoietic, fibroblast and epithelial lineage, where it resides primarily in the nucleus. In neurons and osteoclasts, its primary localization is in cytoplasm, thus suggesting its shuttles between nucleus and cytoplasm.

免疫原

Immunogen Sequence: GI # 4506929, sequence 1-360
Recombinant SH3-domain GRB2-like 1

应用

Anti-SH3GL1 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

生化/生理作用

SH3GL1 (SH3-domain GRB2-like 1) or endophilin-A2 is involved in the formation of endocytic vesicles. The protein is a 50- to 60-amino-acid module carried by intracellular proteins involved in the transduction of signals for cell polarization, motility, enzymatic activation, and transcriptional regulation. SH3GL1 is expressed ubiquitously. It is one of the main accessory proteins involved in clathrin-mediated endocytosis and it interacts with other endocytic proteins, such as dynamin, by its SH3 domain. SH3GL1 may be one of the pathogenic genes for idiopathic scoliosis (IS) and may be associated with adolescent idiopathic scoliosis (AIS). It may have some role in the cell cycle. SH3GL1 may be involved in the oncogenic process of gliomas.

外形

Solution in phosphate buffered saline containing 0.02% sodium azide.

基本信息

NACRESNA.41

产品性质

生物来源chicken
质量水平200
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
species reactivityrat, human, mouse
technique(s)western blot: suitable
NCBI登记号NP_003016.1
UniProt登记号Q6FGM0
运输wet ice
储存温度−20℃
Gene Informationhuman ... SH3GL1(6455)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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