产品说明
应用
Cholesterol was used for preparing ISCOMS containing ovalbumin (OVA) for studying whether the incorporation of the protein antigen ovalbumin (OVA) in lipophilic immune-stimulating complexes (ISCOMS) induces very strong primary immune responses. It was incorporated in animal feed to study the effect of cholesterol-rich diet.
生化/生理作用
Cholesterol is a lipid that makes up about 20-25% of the structural components of the cell membranes. It determines the fluidity and permeability of the membrane, making it permeable to water but not to ions and protons. Cholesterol also regulates the functions of the transporters and signaling proteins present on the plasma membrane. The major sites of cholesterol synthesis are small intestine and liver.
所有生物膜的主要成分；总脑脂质中含 ~25% 的胆固醇。
基本信息
| 经验(实验)分子式 | C27H46O |
| 分子量 | 386.65 |
| Beilstein | 1915888 |
| EC 号 | 200-353-2 |
| MDL编号 | MFCD00003646 |
| PubChem化学物质编号 | 329750548 |
| NACRES | NA.21 |
产品性质
| 质量水平 | 100 |
| agency | USP/NF tested according to Ph. Eur. |
| 形式 | powder |
| bp | 360 ℃ (lit.) |
| mp | 147-149 ℃ (lit.) |
| 溶解性 | chloroform: soluble 1 gm in 4.5 ml diethyl ether: soluble 1 gm in 2.8 ml pyridine: soluble 1 gm in 1.5 ml H2O: insoluble acetone: soluble alcohol: slightly soluble alcohol: very soluble (Hot) benzene: soluble dioxane: soluble ethyl acetate: soluble hexane: soluble oil: soluble petroleum ether: soluble |
| 密度 | 1.067 g/mL at 25 ℃ (lit.) |
| application(s) | pharmaceutical (small molecule) |
| 储存温度 | 2-8℃ |
| SMILES string | CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C |
| InChI | 1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 |
| InChI key | HVYWMOMLDIMFJA-DPAQBDIFSA-N |
| Gene Information | human ... POLA1(5422), TOP2A(7153) rat ... Ar(24208), Polb(29240) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
Sigma-Aldrich
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