产品说明
免疫原
synthetic peptide corresponding to the N-terminal extracellualr domain of human metabotropic glutamate receptor 6, conjugated to KLH. The immunizing peptide has 100% homology with the rat and mouse gene.
应用
Anti-Glutamate Receptor 6, Metabotropic antibody is suitable for immunohistochemistry (formalin-fixed, paraffin-embedded sections) at a concentration of 12μg/mL using human ganglion layer, retina.
生化/生理作用
Glutamate, the excitatory neurotransmitter, is involved in fast excitatory synaptic transmission. It acts on ligand-gated receptor channels, termed NMDA, AMPA and kainate receptors. The metabotropic form consist of eight subtypes (mGluR1-8) divided into three groups (I-III). Group I binds to phospholipase C and intracellular calcium mobilization, whereas both groups II and III inhibit adenyl cyclase. The metabotropic receptors have some therapeutic potentials. group I receptors have been implicated in post-ischemic neuronal injury, and antagonists of group I appear to have a neuroprotective effect.
外形
Solution in phosphate buffered saline, pH 7.7, containing 0.01% sodium azide.
基本信息
| MDL编号 | MFCD03097014 |
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 200 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| species reactivity | human |
| availability | not available in Japan |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 12 μg/mL using human ganglion layer, retina |
| UniProt登记号 | O15303 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... GRM6(2916) mouse ... Grm6(108072) rat ... Grm6(24419) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | nwg |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
