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Anti-EGFR (Ab-1172) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4300472
规格纯度
affinity isolated antibody
参考价格
5045.46 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-EGFR (Ab-1172) antibody produced in rabbit
Anti-epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) antibody produced in rabbit
Anti-ERBB1 antibody produced in rabbit
Anti-ERBB antibody produced in rabbit
Anti-PIG61 antibody produced in rabbit
Anti-HER1 antibody produced in rabbit
产品介绍:

产品说明

一般描述

Epidermal growth factor receptor (EGFR, ErbB1) is a transmembrane protein that exerts tyrosine kinase activity upon ligand induced activation. EGFR can be activated by binding EGF or at least six other structurally related protein ligands, including transforming growth factor-α (TGF-α), heparin-binding EGF-like growth factor (HB-EGF), betacellulin (BTC), amphiregulin, epiregulin and epigen. The gene encoding it is localized on human chromosome 7p11.2.

免疫原

Peptide sequence around aa. 1170-1174 (P-D-Y-Q-Q), according to the protein EGFR.

生化/生理作用

Upon activation by ligands, epidermal growth factor receptor (EGFR, ErbB1) initiates a signaling cascade which includes dimerization and internalization, tyrosine phosphorylation, DNA synthesis of target genes, and, ultimately, cell proliferation. EGFR signaling plays a role in the growth and differentiation of normal cells, but elevated EGFR activity is correlated with the development and pathogenesis of certain cancers.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

目标描述

Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with SRC and CTNNB1/beta-catenin.

外形

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量 ~175 kDa
species reactivityhuman, rat, mouse
浓度1 mg/mL
technique(s)western blot: 1:500-1:1000
同位素/亚型IgG
免疫原序列(P-D-Y-Q-Q)
NCBI登记号NP_005219.2
UniProt登记号P00533
运输wet ice
储存温度−20℃
Gene Informationhuman ... EGFR(1956)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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