产品说明
一般描述
Icilin is a synthetic cooling agent and modulates human transient receptor potential cation channel (TRPA1). Icilin inhibits transient receptor potential cation channel subfamily M member 8 (TRPM8) and modulates calcium release. Icilin also suppresses transient receptor potential vanilloid subtype 3 (TRPV3).
应用
Icilin has been used as cooling agent in anterior ventromedial preoptic area (VMPO) neurons.
包装
10, 50 mg in glass bottle
生化/生理作用
Icilin is a potent agonist at the CMR1 cold- and menthol-sensitive receptor.
基本信息
| 经验(实验)分子式 | C16H13N3O4 |
| 分子量 | 311.29 |
| MDL编号 | MFCD01689072 |
| PubChem化学物质编号 | 24277906 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥97% (HPLC) |
| 形式 | solid |
| 颜色 | yellow |
| 溶解性 | DMSO: 15 mg/mL |
| SMILES string | Oc1ccccc1N2CC=C(NC2=O)c3cccc(c3)[N+]([O-])=O |
| InChI | 1S/C16H13N3O4/c20-15-7-2-1-6-14(15)18-9-8-13(17-16(18)21)11-4-3-5-12(10-11)19(22)23/h1-8,10,20H,9H2,(H,17,21) |
| InChI key | RCEFMOGVOYEGJN-UHFFFAOYSA-N |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
Sigma-Aldrich
m.cnreagent.com
