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Monoclonal Anti-LRP1 antibody produced in mouse

品牌
Sigma-Aldrich
货号
L2420
规格纯度
~1.0 mg/mL, clone LRP1-11, purified immunoglobulin, buffered aqueous solution
参考价格
6923.34 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Monoclonal Anti-LRP1 antibody produced in mouse
Anti-Lipoprotein receptor-related protein
Anti-Apolipoprotein receptor
Anti-A2MR
Anti-LRP
Anti-Low density lipoprotein receptor-related protein 1
Anti-APOER
Anti-APR
Anti-Apolipoprotein E receptor
Anti-CD91
产品介绍:

产品说明

一般描述

Monoclonal Anti-LRP1 (mouse IgG1 isotype) is derived from the hybridoma LRP1-11 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a fragment of human LRP1, conjugated to KLH. LDL receptor family. Low-density lipoprotein (LDL) receptor related protein 1 (LRP1) gene is mapped to human chromosome 12q13.3. LRP1 protein, belongs to the LDL receptor family. LRP1, a single-chain 600 kDa type I transmembrane glycosylated precursor protein, is produced in the endoplasmic reticulum. This protein is proteolytically cleaved in the Golgi complex into two subunits including 85-kDa membrane-bound C-terminal membrane spanning subunit and a noncovalently attached 515-kDa N-terminal subunit.

特异性

Monoclonal Anti-LRP1 recognizes human, rat, and mouse LRP1.

应用

Monoclonal Anti-LRP1 antibody produced in mouse has been used in:

  • immunoblotting
  • enzyme linked immunosorbent assay
  • immunofluorescence

生化/生理作用

Low density lipoprotein receptor related protein 1 (LRP1) plays an essential role in early stages of embryonic development. It aids in lipoprotein metabolism, proteinase regulation, activation of lysosomal enzymes and cellular entry of viruses and toxins. Additionally, It is also implicated in cell signaling pathways, cell migration, and neurodevelopment. LRP1 interacts with at least 30 different ligands including lipoproteins, proteinases, proteinase-inhibitor complexes, extra cellular matrix (ECM) proteins and various intracellular proteins. Furthermore, LDL receptor related protein 1 also has an ability to associate with bacterial toxins and viruses.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

储存及稳定性

Store at –20 ℃. For continuous use, store at 2–8 ℃ for up to one month. For extended storage, freeze at –20 ℃ in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discard if not used within 12 hours.

免责声明

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

质量水平200
生物来源mouse
偶联物unconjugated
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆LRP1-11, monoclonal
形式buffered aqueous solution
分子量antigen ~500 kDa
species reactivitymouse, human, rat
浓度~1.0 mg/mL
technique(s)indirect immunofluorescence: suitable
western blot: 1-2 μg/mL
同位素/亚型IgG1
UniProt登记号Q07954
运输dry ice
储存温度−20℃
Gene Informationhuman ... LRP1(4035)
mouse ... Lrp1(16971), Lrp1(299858)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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