产品说明
一般描述
The H1047R substitution is a somatic mutation in p110α that has been associated with tumours of the colon, stomach, breast and brain. Combined in vitro and in vivo studies have shown that this mutation confers higher lipid kinase activity than wild type, and is able to induce oncogenic transformation. (Samuels Y. et al., Science, (2004); 304: 554; Kang S. et al., PNAS, (2005);102: 802-807 and Zhao J.J. et al., PNAS, (2005);102:18443-18448).
Complex of N-terminal 6His-tagged recombinant human p110α full length, containing the mutation H1047R, and untagged, recombinant, human p85α full length.
生化/生理作用
Protein Target: PI3Kα/p85α
Target Sub-Family: PI3K/PI4K
包装
Also available in 250μg size --call for pricing and availability and reference catalog number 14-792M when ordering the 250μg size.
外形
50 mM Tris/HCl pH8.0, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 0.2 mM PMSF, 1 mM benzamidine, 0.1% 2-mercaptoethanol. Frozen solution.
Ni2+/NTA-agarose
其他说明
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
eCl@ss | 32160405 |
NACRES | NA.32 |
产品性质
质量水平 | 100 |
生物来源 | human |
分子量 | Mw 125 kDa (p110α(H1047R)) Mw 84 kDa (p85α) |
manufacturer/tradename | Upstate® |
UniProt登记号 | P26450 (mouse) P27986 P42336 P42337 (mouse) U79143 |
Gene Information | human ... PIK3CA(5290) |
安全信息
象形图 | |
警示用语: | Warning |
危险声明 | H317 |
预防措施声明 | P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364 |
危险分类 | Skin Sens. 1 |
储存分类代码 | 10 - Combustible liquids |
WGK | WGK 1 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich