Alantolactone

产品名称：

546-43-0
Alantolactone
Eupatal
NSC 333843
(+)-Alantolactone.
3aR,5S,8aR,9aR)-3a,5,6,7,8,8a,9,9a-Octahydro-5,8a-dimethyl-3-methylene-naphtho[2,3-b]furan-2(3H)-one
Elecampane camphor
NSC 93131
Inula camphor
Alant camphor

产品介绍：

产品说明

一般描述

Alantolactone is a compound produced by Inula helenium. Alantolactone has antibacterial, antifungal, anti-inflammatory and anticancer properties. It suppresses signal transducer and activator of transcription 3 (STAT3) activation in liver and breast cancer cells. Alantolactone induces apoptosis in A549 lung cancer cells.

应用

Alantolactone has been used:

in cell viability assay
to examine the percentage of multicentrosomal mitosis in low and high passage human embryonic stem cells (hESC)
in assessment of degranulation

包装

5, 25 mg in glass bottle

生化/生理作用

Alantolactone is a sesquiterpene lactone disrupts the Cripto-1/ActRII complexes, resulting in an induction of activin/SMAD3 signaling. Alantolactone inhibits proliferation in cancer cells with no affect on normal cells.

基本信息

经验(实验)分子式	C₁₅H₂₀O₂
分子量	232.32
EC 号	208-899-3
MDL编号	MFCD00274568
PubChem化学物质编号	329825410
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
储存条件	desiccated protect from light
颜色	white to beige
溶解性	DMSO: 15 mg/mL (clear solution)
储存温度	−20℃
SMILES string	C[C@H]1CCC[C@]2(C)C[C@H]3OC(=O)C(=C)[C@H]3C=C12
InChI	1S/C15H20O2/c1-9-5-4-6-15(3)8-13-11(7-12(9)15)10(2)14(16)17-13/h7,9,11,13H,2,4-6,8H2,1,3H3/t9-,11+,13+,15+/m0/s1
InChI key	PXOYOCNNSUAQNS-AGNJHWRGSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H317
预防措施声明	P261 - P272 - P280 - P333 + P313 - P362 + P364 - P501
危险分类	Skin Sens. 1
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable