产品说明
应用
Penciclovir is a selective antiherpesvirus agent, particularly against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) and varicella-zoster virus (VZV).
包装
100 mg in glass bottle
生化/生理作用
Penciclovir is converted to its active form, penciclovir triphosphate, by cellular kinases. It inhibits viral DNA polymerase by competing with deoxyguanosine triphosphate. It inhibits DNA synthesis of virus-infected cells. Penciclovir has in vitro activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2). It does not inhibit DNA synthesis in non-infected cells. Mode of resistance is via qualitative changes in viral thymidine kinase or DNA polymerase.
其他说明
Keep container tightly closed in a dry and well-ventilated place.
基本信息
经验(实验)分子式 | C10H15N5O3 |
分子量 | 253.26 |
MDL编号 | MFCD15142866 |
PubChem化学物质编号 | 329819986 |
产品性质
质量水平 | 100 |
溶解性 | 0.02 M potassium phosphate: soluble 2 mg/mL |
作用机制 | DNA synthesis | interferes enzyme | inhibits |
抗生素抗菌谱 | viruses |
SMILES string | NC1=NC(=O)c2ncn(CCC(CO)CO)c2N1 |
InChI | 1S/C10H15N5O3/c11-10-13-8-7(9(18)14-10)12-5-15(8)2-1-6(3-16)4-17/h5-6,16-17H,1-4H2,(H3,11,13,14,18) |
InChI key | JNTOCHDNEULJHD-UHFFFAOYSA-N |
安全信息
储存分类代码 | 13 - Non Combustible Solids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich