Raltitrexed

产品名称：

Raltitrexed
L-Glutamic acid, N-((5-(((1,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl)methylamino)-2-thienyl)carbonyl)
ICI-D-1694
ZD-1694

产品介绍：

产品说明

包装

10 mg in glass bottle
50 mg in poly bottle

生化/生理作用

Raltitrexed is a folate-based inhibitor of thymidylate synthase (TS) that is rapidly and extensively metabolized to its more potent polyglutamate derivatives. By inhibiting the formation of precursor pyrimidine nucleotides, raltitrexed prevents the formation of DNA and RNA, which are required for the growth and survival of both normal cells and cancer cells.

特点和优势

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

基本信息

经验(实验)分子式	C₂₁H₂₂N₄O₆S
分子量	458.49
PubChem化学物质编号	329824044

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
颜色	off-white to light yellow
溶解性	H₂O: ≥10 mg/mL DMSO: ≥40 mg/mL
创始人	AstraZeneca
储存温度	2-8℃
SMILES string	O=C1NC(C)=NC2=C1C=C(CN(C3=CC=C(C(N[C@H](CCC(O)=O)C(O)=O)=O)S3)C)C=C2

安全信息

象形图
警示用语：	Danger
危险声明	H300 - H360
预防措施声明	P201 - P301 + P310 + P330
危险分类	Acute Tox. 2 Oral - Repr. 1B
储存分类代码	6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges