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Anti-Seladin-1 antibody produced in rabbit

Anti-Seladin-1 兔抗

品牌
Sigma-Aldrich
货号
S8571
规格纯度
IgG fraction of antiserum, buffered aqueous solution
参考价格
4330.86 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-Seladin-1 antibody produced in rabbit
Anti-24-dehydro-cholesterol reductase (DCHR24), Diminuto/Dwarf-1 homolog
Anti-Selective Alzheimer’s Disease Indicator-1
Anti-Seladin-1 兔抗
产品介绍:

产品说明

一般描述

Seladin-1 (selective Alzheimer′s disease indicator-1) is an anti-apoptotic gene. It is a human homolog of the Diminuto/Dwarf1 gene described in plants andC. elegans. Seladin-1 is encoded by the DHCR24 (3-b-hydroxysterol-D-24-reductase) gene, a flavin-adenine-dinucleotide (FAD)-dependent oxidoreductase. It is mainly located in the endoplasmic reticulum.

免疫原

synthetic peptide corresponding to amino acids 68-85 of human seladin-1, conjugated to KLH.

应用

Anti-Seladin-1 antibody produced in rabbit has been used in immunoblotting.

生化/生理作用

Seladin-1 (selective Alzheimer′s disease indicator-1) catalyzes the conversion of desmosterol to cholesterol. It prevents apoptosis via inhibition of caspase-3, a key mediator of the apoptotic cascade, suggesting that seladin-1 may be involved in the regulation of cell survival and death. Decreased expression of seladin-1 in specific neurons is linked to Alzheimer′s disease (AD). Seladin-1 functions as a key mediator of Ras-induced senescence in mouse and human fibroblasts. It protects neurons from β-amyloid toxicity and oxidative stress. Seladin-1 is involved in cholesterol homeostasis.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD09265376
NACRESNA.41

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式IgG fraction of antiserum
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量antigen ~60 kDa
species reactivityhuman
增强验证recombinant expression
Learn more about Antibody Enhanced Validation
technique(s)western blot: 1:4,000-1:8,000 using HEK293 cells expressing human seladin-1.
UniProt登记号Q15392
运输dry ice
储存温度−20℃
Gene Informationhuman ... DHCR24(1718)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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