2,4-二氨基-5-(3,4,5-三甲氧基苄基)嘧啶乳酸盐

产品名称：

23256-42-0
Trimethoprim lactate salt
2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine lactate salt
甲氧苄啶乳酸盐
2,4-二氨基-5-(3,4,5-三甲氧基苄基)嘧啶乳酸盐

产品介绍：

产品说明

一般描述

Chemical structure: pyrimidine

应用

Trimethoprim is primarily used as an antibacterial agent. It has dihydrofolate reductase inhibitor activity with selectivity for the prokaryote enzyme. It is used clinically to treat urinary tract infections, mild acute prostatitis, recurrent cystitis, asymptomatic bacteriuria during pregnancy and respiratory tract infections. Trimethoprim lactate salt is used as a selection agent.

包装

250 mg in glass bottle

生化/生理作用

The combination of trimethoprim and sulfamethoxazole interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to prokaryote-specific dihydrofolate reductase (DHFR) and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis.

其他说明

Keep container tightly closed in a dry and well-ventilated place.

基本信息

经验(实验)分子式	C₁₄H₁₈N₄O₃ · C₃H₆O₃
分子量	380.40
EC 号	245-533-1
MDL编号	MFCD00171722
PubChem化学物质编号	329826610
NACRES	NA.85

产品性质

质量水平	200
测定	≥98%
形式	powder
储存条件	(Keep container tightly closed in a dry and well-ventilated place.)
颜色	white
溶解性	H₂O: soluble 20 mg/mL
作用机制	DNA synthesis \| interferes enzyme \| inhibits
抗生素抗菌谱	Gram-negative bacteria Gram-positive bacteria mycobacteria
储存温度	2-8℃
SMILES string	CC(O)C(O)=O.COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC
InChI	1S/C14H18N4O3.C3H6O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-2(4)3(5)6/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2,4H,1H3,(H,5,6)
InChI key	IIZVTUWSIKTFKO-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H301 - H361d
预防措施声明	P202 - P264 - P270 - P280 - P301 + P310 - P405
危险分类	Acute Tox. 3 Oral - Repr. 2
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)

Trimethoprim lactate salt

甲氧苄啶 乳酸盐

甲氧苄啶乳酸盐