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Anti-TTP (C-terminal) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
T5452
规格纯度
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
参考价格
6627.19 *本价格含增值税费
促销
服务
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  • 增值税票
数量
-+
产品名称:
Anti-TTP (C-terminal) antibody produced in rabbit
Anti-Zfp36, Zinc finger protein 36 homolog Protein
Anti-Tristetraprolin
Anti-NUP475
Anti-RNF162A
Anti-G0/G1 switch regulatory protein 24
Anti-TIS11
Anti-Growth factor-inducible nuclear protein NUP475
Anti-GOS24
产品介绍:

产品说明

一般描述

TTP is also known as Tristetraproline, Zfp-36, TIS11A, and Growth factor-inducible nuclear protein NUP475. TTP belongs to a family of human ARE (AU-rich element found in 3′ UTR mRNA) binding protein that contains tandem CCCH zinc finger RNA-binding domains required for interaction with ARE. TTP is a phosphoprotein. Anti-TTP (C-terminal) is produced in rabbit using as immunogen a synthetic peptide corresponding to human TTP conjugated to KLH.

免疫原

synthetic peptide corresponding to amino acids 270-284 of human TTP conjugated to KLH. The corresponding sequence differs by one amino acid in mouse and rat.

应用

Anti-TTP (C-terminal) antibody has been used in immunoprecipitationand may be used for immunoblotting.

生化/生理作用

Tristetraprolin (TTP) is an RNA-binding protein that suppresses inflammation by accelerating the degradation of cytokine mRNA. TTP plays a role in both mRNA deadenylation and 3′ to 5′ degradation of the mRNA and helps in recruiting several factors involved in these processes. TTP acts as a substrate for multiple kinases like ERK (extracellular signal-regulated kinases), JNK (Jun N-terminal kinase) , p38, and MAPKAPK2.

目标描述

TTP (C-terminal) (also known as Tristetraproline, Zfp-36, TIS11A, and Growth factor-inducible nuclear protein NUP475) is an RNA-binding protein that suppresses inflammation by accelerating the degradation of cytokine mRNA.

外形

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量antigen ~50 kDa
species reactivityhuman
浓度~1.0 mg/mL
technique(s)western blot: 0.5-1.0 μg/mL using lysates of HEK-293 cells overexpressing human TTP
UniProt登记号P26651
运输dry ice
储存温度−20℃
Gene Informationhuman ... ZFP36(7538)
mouse ... Zfp36(22695)
rat ... Zfp36(79426)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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