产品说明
一般描述
WAS protein family member 1 (WAVE-1) is encoded by the gene mapped to human chromosome 6q21. The encoded protein contains small WH2 acidic domain, a cofilin-like domain, proline-rich domain at C-terminal end and EVH1 domain at N-terminal end. WAVE-1 is active mainly in the brain and lungs, but its mRNA is also found in the placenta, liver and pancreas.
生化/生理作用
WAS protein family member 1 (WAVE-1) functions as a key pro-autophagic protein. The protein has an ability to increase cell survival rate. In addition, it also controls chemoresistance in leukemia cells via Beclin1/ B-cell lymphoma 2 (Bcl)-2 and Beclin1/ phosphatidylinositol 3-kinases (PI3K)-III complex-dependent pathways. The encoded protein enhances ovarian cancer cell proliferation, migration and invasion via activating PI3K/AKT (protein kinase B) and mitogen activated protein kinase p38 (p38MAPK) signaling pathways.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 200 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen ~75 kDa |
| species reactivity | rat (predicted), human (predicted), mouse |
| 浓度 | ~1.5 mg/mL |
| technique(s) | western blot: 1-2 μg/mL using mouse brain extract (S1 fraction) |
| UniProt登记号 | Q92558 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... WASF1(8936) mouse ... Wasf1(83767) rat ... Wasf1(294568) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
Sigma-Aldrich
m.cnreagent.com
