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Anti-JNK antibody, Mouse monoclonal

品牌
Sigma-Aldrich
货号
SAB4200176
规格纯度
clone 1C2, purified from hybridoma cell culture
参考价格
5705.99 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-JNK antibody, Mouse monoclonal
Anti-JNK-46
Anti-PRKM8
Anti-JNK1
Anti-MAPK8
Anti-MAP kinase 8
Anti-JUN N-terminal kinase
Anti-SAPK1
Anti-JNK1A2
Anti-JNK21B1/2
Anti-stress-activated protein kinase 1
产品介绍:

产品说明

一般描述

Anti-JNK antibody, Mouse monoclonal, (mouse IgG2a isotype) is derived from the hybridoma 1C2 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a recombinant protein. JNK1 (c-Jun N-terminal kinase), also known as MAPK8 (mitogen-activated protein kinase 8) is a member of the MAP kinase family. This gene is mapped to human chromosome 10q11.

应用

Anti-JNK antibody, Mouse monoclonal has been used in immunoblotting and enzyme linked immunosorbent assay (ELISA).

生化/生理作用

JNK1 is also involved in UV (ultra violet) radiation induced apoptosis, which is thought to be related to cytochrome C-mediated cell death pathway.
JNK1 (or MAPK8) is a serine threonine kinase that is a key regulator of cellular apoptosis. During the lack of NFkB stiμLation; persistent activation of JNK1 results in TNF-a induced cell death. However, JNK1 may also function as an apoptotic inhibitor. For instance; JNK1 interacts with WOX1 to inhibit apoptosis. Furthermore, JNK1 phosphorylates Bcl-2 to mediate starvation-induced autophagy, and also activates SIRT1 by phosphorylation during conditions of oxidative stress. JNK1 is activated by UV irradiation and oncoproteins and hence may be implicated in cancer propagation
Monoclonal Anti-JNK antibody is specific for human, mouse and rat JNK1 (43 kDa) and/or JNK2 (55 kDa).

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD00802809
NACRESNA.44

产品性质

生物来源mouse
偶联物unconjugated
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆1C2, monoclonal
分子量antigen ~43 kDa
species reactivityhuman, rat, mouse
浓度~1.0 mg/mL
technique(s)western blot: 1-2 μg/mL using using whole extracts of mouse NIH-3T3 cells
同位素/亚型IgG2a
UniProt登记号P45983
运输dry ice
储存温度−20℃
Gene Informationhuman ... MAPK8(5599)
mouse ... Mapk8(26419)
rat ... Mapk8(116554)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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