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Anti-CD4 Antibody (human), PE, clone OKT4

品牌
Sigma-Aldrich
货号
MABF417
规格纯度
clone OKT4, from mouse
参考价格
3841.74 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-CD4 Antibody (human), PE, clone OKT4
T-cell surface glycoprotein CD4, T-cell surface antigen T4/Leu-3, CD antigen CD4
产品介绍:

产品说明

一般描述

The OKT4 antibody reacts with human CD4, a 59 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4, and co-receptors CCR5 and CXCR4, may also be utilized by HIV-1 to enter T cells. Human CD4 is typically expressed on thymocytes, some mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells.The OKT4 antibody is widely used as a phenotypic marker for CD4 expression. It is cross-reactive with CD4 in several non-human species, including Chimpanzee, Cynomolgus and Rhesus. This antibody recognizes a different epitope, and thus does not block binding of, the alternative Anti-Human CD4 antibody clone RPA-T4 (Reinherz EL, et al. 1979. Proc. Natl. Acad. Sci. 76:4061-4065)

免疫原

Immunogen information for this antibody is proprietary information.

应用

This Mouse Monoclonal Antibody Anti-CD4 (human), PE, clone OKT4, Cat. No. MABF417 is validated for use in WB, IF, FC for the detection of CD4.
Research Category
Inflammation & Immunology

外形

Size Exclusion Chromatography
Purified Mouse Monoclonal Antibody in buffer containing 10 mM NaH2PO4, 150 mM NaCl, 0.1% gelatin, pH 7.2, and up to 0.1% sodium azide.

储存及稳定性

It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

质量水平100
生物来源mouse
偶联物PE
抗体形式purified antibody
antibody product typeprimary antibodies
克隆OKT4, monoclonal
species reactivityhuman
包装pkg of 5 μL (0.06 μg/test)
technique(s)flow cytometry: suitable
immunofluorescence: suitable
western blot: suitable
同位素/亚型IgG2bκ
UniProt登记号P01730
运输wet ice

安全信息

储存分类代码12 - Non Combustible Liquids
WGKnwg
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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