Anti-EPS15 antibody produced in rabbit

产品说明

一般描述

EGFR pathway substrate 15 (Eps15) is an endocytic adaptor protein. It contains three N-terminal conserved EH (epsl5 homology) protein-protein interaction domains, a central coiled-coil region, and a C-terminal domain containing the adapter protein (AP)-2 and AP-1 binding domains. The C-terminal domain also contains two ubiquitin interaction motifs (UIMs), required for Eps15 binding to ubiquitin. Eps15 colocalizes with markers of the plasma membrane clathrin-coated pits and vesicles.

免疫原

synthetic peptide corresponding to an internal sequence of human EPS15 isoform A (GeneID: 2060), conjugated to KLH. The corresponding sequence is identical in human EPS15 isoform B, and in rat and mouse EPS15.

应用

Anti-EPS15 antibody produced in rabbit has been used in several immunochemical techniques including:

• immunoblotting
• immunofluorescence
• immunohistochemistry

生化/生理作用

Epidermal growth factor (EGFR) pathway substrate 15 (Eps15), that plays a central role in the clathrin mediated internalization and degradation of EGFR. Eps15 is required in clathrin mediated endocytosis including of synaptic vesicles. This protein has been shown to regulate the endosomal trafficking of EGFR, possibly through the recruitment of the ubiquitinated receptors to the rims of clathrin-coated pits. The EPS15 gene yields two isoforms that are believed to reside in distinct subcellular locations and thus implicated in different aspects of endosomal trafficking.

外形

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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