产品说明
一般描述
The PAK1 (p21 (RAC1) activated kinase 1) gene is mapped to human chromosome 11q13.5-q14.1. It belongs to the family of serine/threonine kinases and the gene is evolutionarily conserved.
Anti-PAK1 antibody detects endogenous levels of total PAK1 protein.
免疫原
The antiserum was produced against synthesized peptide derived from human PAK1.
Immunogen Range: 178-227
生化/生理作用
PAK1 (p21 (RAC1) activated kinase 1) maintains the cytoskeleton and cellular morphology. It is associated with cell cycle, cell motility, survival, and cell death. PAK1 is upregulated in different types of cancer. PAK1 is found to be involved in growth, invasion, and metastasis of cancer cells, as it affects the action of pro-apoptotic signals. In neurodegenerative diseases, such as Huntington′s disease and Alzheimer′s disease, and mental retardation, abnormal regulation of PAK1 is observed. PAK1 induces MAPK (mitogen activated protein kinase) signal pathway and cytoskeletal remodeling in breast cancer, thereby serving as an oncogene. PAK1 is known to significantly participate in the development, maturation and plasticity of the nervous system.
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
基本信息
| MDL编号 | MFCD03455286 |
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen 60 kDa |
| species reactivity | mouse, rat, human |
| 浓度 | ~1 mg/mL |
| technique(s) | ELISA: 1:1000 immunofluorescence: 1:100-1:500 immunohistochemistry: 1:50-1:100 western blot: 1:500-1:1000 |
| NCBI登记号 | Q13153 |
| UniProt登记号 | Q13153 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... PAK1(5058) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | nwg |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
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