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sTNF-receptor Type I human

品牌
Sigma-Aldrich
货号
SRP3162
规格纯度
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
参考价格
4582.93 *本价格含增值税费
促销
服务
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  • 增值税票
数量
-+
产品名称:
sTNF-receptor Type I human
TNFAR
TNFRSF1A
TNF-R55
Soluble Tumor Necrosis Factor type I
产品介绍:

产品说明

一般描述

TNFR1 (tumor necrosis factor receptor 1) gene is localized to human chromosome 12p13, and encodes a 55kDa receptor showing a wide range of tissue expression. This receptor belongs to the family of receptors which contain repeating cysteine-rich extracellular motifs. TNFR1 contains a protein-protein interacting domain called death domain containing ∼70 amino acids. It also contains a silencer of death domains (SODD), a 60kDa domain, which inhibits ligand-independent self-association of TNFR1. TNFR1 is a member of the TNFR family, which are type I transmembrane proteins.
Recombinant human sTNFR1 is an 18.3 kDa protein (162 amino acid residues) comprising the cysteine rich ligand binding portion of the extracellular domain of the TNFR1 protein.

生化/生理作用

TNFR1 (tumor necrosis factor receptor 1) is involved in inflammatory responses, and the cleavage of the membrane form leads to production of soluble TNFR1. The soluble form competes with the membrane-bound form, and this leads to a reduction in the severity of the inflammatory responses. Mutations in this gene resulting in the disruption of conserved extracellular disulfide bonds, leads to lower levels of soluble TNFR1 forms, which is linked with autosomal dominant periodic fever syndromes, characterized by unexplained recurrent fevers and severe localized inflammation. Studies in two independent community-based elderly cohorts show that sTNFR1 is linked with increased mortality in cardiovascular and cancer cases.

序列

MDSVCPQGKY IHPQNNSICC TKCHKGTYLY NDCPGPGQDT DCRECESGSF TASENHLRHC LSCSKCRKEM GQVEISSCTV DRDTVCGCRK NQYRHYWSEN LFQCFNCSLC LNGTVHLSCQ EKQNTVCTCH AGFFLRENEC VSCSNCKKSL ECTKLCLPQI EN

外形

Lyophilized from 10 mM Tris, pH 8.0 + 20 mM NaCl.

重悬

Centrifuge the vial prior to opening. Reconstitute in 5 mM Tris, pH 8.0 to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20℃ to -80℃.

基本信息

NACRESNA.32

产品性质

生物来源human
重组expressed in E. coli
测定≥98% (HPLC)
≥98% (SDS-PAGE)
形式lyophilized
效能0.25 ng/mL ED50
分子量 18.3 kDa
包装pkg of 20 μg
technique(s)cell culture | mammalian: suitable
杂质<0.1 EU/μg endotoxin, tested
颜色 white
UniProt登记号P19438
运输wet ice
储存温度−20℃
Gene Informationhuman ... TNFRSF1A(7132)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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