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WNT-7A human

品牌
Sigma-Aldrich
货号
SRP3296
规格纯度
recombinant, expressed in HEK 293 cells, ≥80% (SDS-PAGE), ≥80% (HPLC)
参考价格
4375.36 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
WNT-7A human
产品介绍:

产品说明

一般描述

Wnt-7a is expressed in placenta, kidney, testis, uterus, fetal lung and fetal and adult brain. Most Wnt proteins can signal though a mechanism called the canonical Wnt pathway, in which Wnt proteins bind to and activate seven-pass transmembrane receptors of the Frizzled family ultimately leading to the disruption of β-Catenein degradation. Intracellular accumulation of β-Catenin increases translocation of the protein into the nucleus where it binds to TCF/LEF transcription factors and induces the expression of numerous genes. Increased Wnt/β-Catenein signaling is associated with tumorigenesis in a diverse set of human cancers. However, Wnt-7a/Frizzled-9 signaling has been shown to act as a tumor suppressor in non-small cell lung cancers.

生化/生理作用

Wnt-7a belongs to the Wnt family of signaling proteins that play a key role in maintaining the integrity of embryonic and adult tissues. Recombinant human Wnt-7a is a 35.5 kDa glycoprotein containing 318 amino acids. Due to glycosylation, Wnt-7a migrates between 40-55 kDa by SDS-PAGE gel under unreduced conditions

外形

Lyophilized with no additives.

重悬

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of ≤0.2 mg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20℃ to -80℃.

基本信息

NACRESNA.32

产品性质

生物来源human
重组expressed in HEK 293 cells
测定≥80% (HPLC)
≥80% (SDS-PAGE)
形式lyophilized
效能40-60 ng/mL ED50
分子量 35.5 kDa
包装pkg of 15 μg
杂质<0.1 EU/μg endotoxin, tested
颜色 white
UniProt登记号O00755
运输wet ice
储存温度−20℃
Gene Informationhuman ... WNT7A(7476)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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