产品说明

一般描述

Adenosylhomocysteinase (AHCY) (EC 3.3.1.1) or S-adenosylhomocysteine hydrolase (SAHH); is an enzyme that catalyzes the reversible hydrolysis of S-adenosyl homocysteine (SAH) to adenosine and homocysteine. AHCY regulates the intracellular SAH concentration which in turn regulates S-adenosyl methionine (SAM)-dependent methyltransferases. Down-regulation of AHCY has been associated with certain forms of cancer and Huntington′s disease, while in Wilson′s disease; the enzyme is inhibited by the accumulated copper. Mutations in the AHCY gene cause SAHH deficiency disease.

适用性

Suitable for the detection of Adenosylhomocysteinase (AHCY) activty in purified recombinant protein or cell and tissue lysate.

原理

The AHCY Activity Assay kit can kinetically measure AHCY activity by detecting adenosine generation resulting from the hydrolysis of SAH. Adenosine is detected via a multi-step reaction, resulting in the generation of an intermediate that reacts with the probe. The fluorescent product is measured at. limit of quantification (LOQ) is 1 U of recombinant human AHCY.

基本信息

产品性质

安全信息

象形图
警示用语：	Danger
危险声明	H312 - H317 - H318 - H334 - H361d - H410
预防措施声明	P202 - P273 - P280 - P302 + P352 + P312 - P305 + P351 + P338 - P308 + P313
危险分类	Acute Tox. 4 Dermal - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1
储存分类代码	10 - Combustible liquids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable