产品说明
一般描述
This gene encodes a member of the thioesterase superfamily. In humans, the protein co-localizes with microtubules and is essential for sustained cell proliferation. The orthologous mouse protein forms a homotetramer and is associated with mitochondria. The mouse protein functions as a medium- and long-chain acyl-CoA thioesterase. Multiple transcript variants encoding different isoforms have been found for this gene
免疫原
ACOT13 (NP_060943.1, 1 a.a. ~ 140 a.a) full-length human protein.
Sequence
MTSMTQSLREVIKAMTKARNFERVLGKITLVSAAPGKVICEMKVEEEHTNAIGTLHGGLTATLVDNISTMALLCTERGAPGVSVDMNITYMSPAKLGEDIVITAHVLKQGKTLAFTSVDLTNKATGKLIAQGRHTKHLGN
应用
Anti-ACOT13 antibody produced in mouse is suitable for western blot anaysis.
生化/生理作用
ACOT13 (Acyl-CoA thioesterase 13) is highly involved in the regulation of hepatic lipid and glucose homeostasis. It maintains the intracellular concentration of hepatic free fatty acids (FFAs) and fatty acyl-CoAs under physiological conditions by forming a complex with phosphatidylcholine transfer protein (PC-TP). In liver, it controls the β-oxidation of fatty acids, which is highly crucial for entry of fatty acyl-CoAs into mitochondria.
外形
Solution in phosphate buffered saline, pH 7.4
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen ~15 kDa |
| species reactivity | human |
| technique(s) | western blot: 1 μg/mL |
| NCBI登记号 | NM_018473.2 |
| UniProt登记号 | Q9NPJ3 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... ACOT13(55856) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
