产品说明
一般描述
Bridging integrator 1 (BIN1) is mapped to human chromosome 2q14.3 and comprises 20 exons. The gene encodes multiple splice variants as close to 10 isoforms. Isoform nine and 10 are ubiquitous, eight is expressed in muscle. Rest other isoforms are expressed in brain. BIN1 comprises N-terminal BAR (Bin1/Amphiphysin/RVS167) domain and C-terminal SRC homology 3 (SH3) domain. It belongs to BAR superfamily and is a membrane deforming protein.
免疫原
Peptide with sequence C-SDNAPAKGNKSPS from the internal region of the protein sequence according to NP_004296.1; NP_647593.1; NP_647594.1; NP_647595.1; NP_647596.1; NP_647597.1; NP_647598.1; NP_647599.1; NP_647600.1; NP_647601.1.
生化/生理作用
Bridging integrator 1 (BIN1) mediates the endosomal vesicle sorting. It also modulates β-site amyloid precursor protein cleaving enzyme 1 (BACE1) and regulates amyloid Aβ production. BIN1 interacts with actin through the BAR domain and also regulates tubulation of T?tubules and clathrin?mediated endocytosis. Single nucleotide polymorphisms in BIN1 and its altered expression is implicated in the pathogenesis of Alzheimer′s disease. Mutations in the BAR domain of the BIN1 leads impairment in T-tubule organization in centronuclear myopathy (CNM).
特点和优势
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外形
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
基本信息
| MDL编号 | MFCD01633055 |
| NACRES | NA.41 |
产品性质
| 生物来源 | goat |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| species reactivity | mouse, bovine, human, rat |
| technique(s) | indirect ELISA: suitable western blot: suitable |
| UniProt登记号 | O00499 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... BIN1(274) |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H315 - H319 |
| 预防措施声明 | P305 + P351 + P338 |
| 危险分类 | Eye Irrit. 2 - Skin Irrit. 2 |
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
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