产品说明
一般描述
Cfl1 (cofilin 1) is also called as actin-depolymerizing factor, an actin binding protein. The CFL1 gene is mapped to human chromosome 11q13.1.
免疫原
Peptide sequence around aa. 1-5 (M-A-S-G-V), according to the protein CFL1.
生化/生理作用
Reorganization of actin cytoskeleton in response to extracellular signals such as TGF-β (transforming growth factor-β) is mediated by CFL1 (cofilin 1), an actin binding protein. CFL1 is closely associated with cell motility and metastasis and regulates invadopodia maturation. Invadopodia are proteins rich in actin and are found in invasive cancer cells and carries out extracellular matrix degradation. Upregulation of CFL1 is observed in a number of cancers including bladder cancer.
特点和优势
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目标描述
Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods.
外形
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | ~19 kDa |
| species reactivity | rat, mouse, human |
| 浓度 | 1 mg/mL |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 western blot: 1:500-1:1000 |
| 同位素/亚型 | IgG |
| 免疫原序列 | (M-A-S-G-V) |
| NCBI登记号 | NP_000213.1 |
| UniProt登记号 | P23528 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... CFL1(1072) |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
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