产品说明
一般描述
Conserved Oligomeric Golgi complex 6 (COG6), also known as COD2, is a member of the conserved oligomeric Golgi (COG) complex. COG complex is composed of eight distinct subunits organized in two heterotrimeric groups, Cog2-Cog3- Cog4 and Cog5-Cog6-Cog7, which are linked by the dimeric group formed by Cog1 and Cog8.
免疫原
a peptide corresponding to the C-terminal region of human COG6, conjugated to KLH. The corresponding sequence differs by three amino acids in mouse and rat COG6.
应用
Anti-COG6 (C-terminal) antibody produced in rabbit has been used in various immunochemical techniques including immunoblotting and immunoprecipitation.
生化/生理作用
COG complex is an evolutionarily conserved multi-subunit protein complex that regulates membrane trafficking and maintenance of Golgi glycosylation machinery in eukaryotic cells. COG complex interacts directly with the target membrane (t-SNARE) Syntaxin 6 through COG6 subunit. COG6-depleted cells display reduced steady-state level of Syntaxin 6 and attenuated endosome-to- trans‐Golgi network (TGN) retrograde trafficking. Deficiency of COG6 causes a combined N- and Oglycosylation deficiency of the congenital disorders of glycosylation, designated as CDG-IIL (COG6- congenital disorders of glycosylation (CDG)).
外形
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen ~70 kDa |
| species reactivity | human |
| 浓度 | ~1.0 mg/mL |
| technique(s) | immunoprecipitation (IP): 5-10 μg using lysates of human HeLa cells western blot: 2-4 μg/mL using whole extracts of human HEK-293T cells |
| UniProt登记号 | Q9Y2V7 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... COG6(57511) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
