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Anti-HMGB1 Antibody, clone HMG1-5H6

品牌
Sigma-Aldrich
货号
MABE148
规格纯度
clone HMG1-5H6, from hamster
参考价格
6526.19 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-HMGB1 Antibody, clone HMG1-5H6
High mobility group protein 1, Sulfoglucuronyl carbohydrate binding protein, high mobility group box 1, high-mobility group (nonhistone chromosomal) protein 1, high-mobility group box 1
产品介绍:

产品说明

一般描述

HMG-1 (High-Mobility-Group protein, amphoterin) is a highly conserved protein with more than 95% amino acid identity between rodent and human HMG-1. It is a prevalent non-histone chromatin component and a non-sequence specific DNA binding protein. HMG-1 consists of two homologous HMG boxes rich in basic amino acids and an acidic tail at the carboxy-terminus. HMG-1 is involved in the regulation of chromatin structure as well as being involved, either as positive or negative factors with various aspects of DNA replication, transcription, repair, and ligation. HMG-1, identified as a membrane associated protein termed “amphoterin,” mediates neurite outgrowth, tumor outgrowth, and metastasis. It participates in plasminogen activation and is recognized as a late mediator of endotoxin lethality in mice.

免疫原

Recombinant protein corresponding to mouse HMGB1.

应用

Research Sub Category
Chromatin Biology

Cell Cycle, DNA Replication & Repair
Use Anti-HMGB1 Antibody, clone HMG1-5H6 (Hamster Monoclonal Antibody) validated in WB, IF, FC to detect HMGB1 also known as High-mobility group box 1.
Immunofluorescence Analysis: 10 µg/mL from a representative lot detected HMGB1 in NIH/3T3 cells. (Image courtesy of Dr. Hideo Yagita, Juntendo University School of Medicine.)

Flow Cytometry Analysis: A representative lot detected HMGB1 in RAW264.7 cells treated with Cytofix/Cytoperm. (Image courtesy of Dr. Hideo Yagita, Juntendo University School of Medicine.)
Research Category
Epigenetics & Nuclear Function

Epigenetics & Nuclear Function

质量

Evaluated by Western Blot in NIH/3T3 cell lysate.

Western Blot Analysis: 1:500 dilution of this antibody detected HMGB1 on 10 µg of NIH/3T3 cell lysate.

目标描述

~ 30 kDa observed

外形

Purified hamster monoclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
NIH/3T3 cell lysate

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

质量水平300
100
生物来源hamster
抗体形式purified antibody
antibody product typeprimary antibodies
克隆HMG1-5H6, monoclonal
species reactivityrat, human, mouse
technique(s)flow cytometry: suitable
immunofluorescence: suitable
western blot: suitable
NCBI登记号NP_034569
UniProt登记号P09429
运输wet ice
Gene Informationhuman ... HMGB1(3146)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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