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Anti-MANEA antibody produced in rabbit

品牌
Sigma-Aldrich
货号
HPA011069
规格纯度
Ab2, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
参考价格
6389.73 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-MANEA antibody produced in rabbit
Anti-Endo-α mannosidase
Anti-HEndo
Anti-Glycoprotein endo-α-1,2-mannosidase
Anti-Mandaselin
Anti-Endomannosidase
产品介绍:

产品说明

一般描述

MANEA (mannosidase, endo-α) is a type II transmembrane glycosidic protein. This enzyme is made of 462 amino acids and has a molecular weight of 53.6kDa. Its transmembrane region is made of 19 amino acids and lies in close proximity to the N-terminal. This gene is present on human chromosome 6q16.1, and is expressed in multiple human tissues including brain, kidney and liver.

免疫原

Glycoprotein endo-α-1,2-mannosidase recombinant protein epitope signature tag (PrEST)

应用

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

生化/生理作用

MANEA (mannosidase, endo-α) catalyzes the cleavage of mono-, di-, and tri-glucosyl-mannose oligosaccharides from high-mannose N-glycans, by breaking the α-1,2-mannosidic bond. Studies also suggest that MANEA is involved in ensuring proper N-glycosylation, and thus provides cells with the ability to recover and mature glycosylated structures. Single nucleotide polymorphisms (SNPs) in this gene are linked to cocaine dependence and cocaine induced paranoia in European American and African American populations. Studies suggest that variations in MANEA gene are associated with anxiety disorder.

特点和优势

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

联系

Corresponding Antigen APREST72260.

外形

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

法律信息

Prestige Antibodies is a registered trademark of sigma-aldrich Co. LLC

基本信息

人类蛋白质图谱编号HPA011069    Human Protein Atlas characterization data

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
产品线Prestige Antibodies® Powered by Atlas Antibodies
形式buffered aqueous glycerol solution
species reactivityhuman
包装antibody small pack of 25 μL
增强验证independent
Learn more about Antibody Enhanced Validation
technique(s)immunohistochemistry: 1:20- 1:50
免疫原序列GVLALSWYPPDVNDENGEPTDNLVPTILDKAHKYNLKVTFHIEPYSNRDDQNMYKNVKYIIDKYGNHPAFYRYKTKTGNALPMFYVYDSYITKPEKWANLLTTSGSRSIRNSPYDGLFIALLVEEKHKYDILQSGFDGIYT
UniProt登记号Q5SRI9
运输wet ice
储存温度−20℃
Gene Informationhuman ... MANEA(79694)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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