Anti-PALB2 antibody produced in rabbit

产品说明

一般描述

Partner and Localizer of BRCA2 (PALB2) gene with 13 exons is mapped to human chromosome 16p12.2. The gene codes for a 1,186 amino acid protein characterized with a coiled-coil motif at the N terminus and a C-terminal domain containing a series of WD repeats.

免疫原

PALB2 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human PALB2.

应用

Anti-PALB2 antibody produced in rabbit has been used in western blot analysis.

生化/生理作用

Partner and Localizer of BRCA2 (PALB2) plays a vital role in BRCA2 (breast cancer 2, early onset)-related pathways. The breast cancer early onset proteins BRCA1 and BRCA2 are central to the repair of DNA damage by homologous recombination and are strongly associated with inherited breast and ovarian cancer. The protein PALB2 is required for the localization of BRCA2 to sites of DNA damage and like BRCA1 and 2 is a breast cancer susceptibility gene. PALB2 is thought to function through directly binding to BRCA1, which allows the PALB2 protein to organize BRCA2 and the recombinase RAD51 at the site of DNA damage. Analysis of the BRCA1-PALB2-BRCA2-RAD51 network may allow predictions to be made of the responsiveness of a tumor to therapeutic treatments. At least four isoforms of PALB2 are known to exist.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

目标描述

The breast cancer early onset proteins BRCA1 and BRCA2 are central to the repair of DNA damage by homologous recombination and are strongly associated with inherited breast and ovarian cancer. The protein PALB2 is required for the localization of BRCA2 to sites of DNA damage and like BRCA1 and 2 is a breast cancer susceptibility gene. PALB2 is thought to function through directly binding to BRCA1, which allows the PALB2 protein to organize BRCA2 and the recombinase RAD51 at the site of DNA damage. Analysis of the BRCA1-PALB2-BRCA2-RAD51network may allow predictions to be made of the responsiveness of a particular tumor to therapeutic treatments. At least four isoforms of PALB2 are known to exist.

联系

The action of this antibody can be blocked using blocking peptide SBP3500079.

外形

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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