Anti-PGRMC1 antibody produced in rabbit

产品说明

免疫原

Synthetic peptide directed towards the N terminal region of human PGRMC1

生化/生理作用

Membrane-associated progesterone receptor component 1 (UniProt: O00264; also known as mPR, PGRMC1) is encoded by the PGRMC1 (also known as HPR6.6, PGRMC) gene (Gene ID: 10857) in human. PGRMC1 is a single pass homodimeric membrane protein that is widely expressed with highest expression observed in liver and kidney. It is also shown to be overexpressed in multiple types of cancers and can serve as an important biomarker of their proliferative state. It has short N-terminal extracellular domain (aa 1-24), a transmembrane domain (aa 25-43), and a cytoplasmic domain (aa 44-195). PGRMC1 is a component of a progesterone-binding protein complex with many cellular functions. It is required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. It also serves as an intracellular heme chaperone that regulates heme synthesis and acts as a heme donor for some hemoproteins. PGRMC1 contains a cytochrome b5 heme-binding domain (aa 72-171) that lacks the conserved iron-binding histidine residue at positions 107 and 131. PGRMC1 is reported to suppress p53 and Wnt/β-catenin pathway to promote self-renewal of pluripotent stem cells (PSCs) and inhibit their differentiation. Its levels are rapidly down regulated during early differentiation of PSCs. (Ref.: Kim, JY et al. (2018). Sci. Rep. 3; 3048; Kim, JY., et al. (2019). Sci. Rep. 9; 653).

序列

Synthetic peptide located within the following region: MAAEDVVATGADPSDLESGGLLHEIFTSPLNLLLLGLCIFLLYKIVRGDQ

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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