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Anti-Phospho-FAS-Y291 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB5700278
包装型号
规格纯度
参考价格
4713.83 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-Phospho-FAS-Y291 antibody produced in rabbit
FAS
APT1
TNFRSF6
FASTM
ALPS1A
FAS1
CD95
Apo-1
产品介绍:

产品说明

一般描述

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.

免疫原

A synthetic phosphorylated peptide around Y291 of human FAS (NP_000034.1).

外形

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

储存及稳定性

Store at -20℃. Avoid freeze / thaw cycles.

产品性质

生物来源rabbit
质量水平100
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量 11
14
16
24
35
37
9
species reactivityhuman
浓度2.24 mg/ml
technique(s)western blot: 1:500-1:2000
UniProt登记号P25445
运输wet ice
储存温度−20℃
Gene Informationhuman ... FAS(355)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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