产品说明
一般描述
Protein kinase D1 (PRKD1) belongs to the protein kinase D family. It is a serine/threonine kinase which is expressed in mammary glands. The gene encoding this protein is localized on human chromosome 14q12.
免疫原
The antiserum was produced against synthesized peptide derived from human PKD1/2/3/PKC mu around the phosphorylation site of Ser738 and Ser742.
Immunogen Range: 706-755
生化/生理作用
Protein kinase D1 (PRKD1) has a role in insulin secretion in the islets of Langerhans. The protein is involved in various cellular processes like DNA synthesis, cell cycle progression, initiation of the nuclear factor κB pathway, vesicular trafficking and apoptosis. It conserves epithelial phenotype by inhibiting epithelial-to-mesenchymal transition. PRKD1 acts as an effector of diacylglycerol and protein kinase C. Protein kinase D2 (PRKD2) is a mediator of tumor cell-endothelial cell communication. PRKD2 influences CD8+ T cell-dependent immune responses. It facilitates cell migration and it is associated with the progression and maintenance of various malignancies.
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen 101 kDa |
| species reactivity | human, mouse, rat |
| 浓度 | ~1 mg/mL |
| technique(s) | ELISA: 1:5000 immunohistochemistry: 1:50-1:100 western blot: 1:500-1:1000 |
| NCBI登记号 | O94806 Q15139 Q9BZL6 |
| UniProt登记号 | Q9BZL6 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... PRKD1(5587), PRKD2(25865), PRKD3(23683) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
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