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Anti-Phospho-RPA2-S4/S8 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB5701887
包装型号
规格纯度
参考价格
5406.77 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-Phospho-RPA2-S4/S8 antibody produced in rabbit
产品介绍:

产品说明

一般描述

As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance.

免疫原

A phospho specific peptide corresponding to residues surrounding S4/S8 of human RPA2.

外形

Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.

产品性质

生物来源rabbit
质量水平100
antibody product typeprimary antibodies
克隆polyclonal
形式liquid
species reactivitymouse, human
浓度1.7 mg/mL
technique(s)western blot: 1:500-1:2000
UniProt登记号P15927
运输wet ice
储存温度−20℃
Gene Informationhuman ... RPA2(6118)

安全信息

闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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