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Anti-Phospho-ULK1-S638 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB5701940
包装型号
规格纯度
参考价格
4266.29 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-Phospho-ULK1-S638 antibody produced in rabbit
产品介绍:

产品说明

一般描述

Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165).

免疫原

A synthetic phosphorylated peptide around S638 of human Phospho-ULK1-S638.

外形

Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.

产品性质

生物来源rabbit
质量水平100
antibody product typeprimary antibodies
克隆polyclonal
形式liquid
species reactivitymouse, human
浓度2.02 mg/mL
technique(s)western blot: 1:500-1:2000
UniProt登记号O75385
运输wet ice
储存温度−20℃
Gene Informationhuman ... ULk1(8408)

安全信息

闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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