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Anti-PMEL antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4200867
规格纯度
affinity isolated antibody, buffered aqueous solution
参考价格
1948.85 *本价格含增值税费
促销
服务
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数量
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产品名称:
Anti-PMEL antibody produced in rabbit
Melanoma gp100
Melanocyte protein
ME20-M (ME20M) Melanoma-associated ME20 antigen
P100
Premelanosome protein
Melanocyte protein Pmel 17
Melanocytes lineage-specific antigen GP100
P1
Silver locus protein homolog
产品介绍:

产品说明

一般描述

The melanocyte-specific protein PMEL (also known as Pmel17, gp100, melanocyte protein, premelanosome protein or silver locus protein homolog (SILV)) is a type I transmembrane glycoprotein that is expressed primarily in pigment cells of the skin and eye. In melanosomes, the protein forms a fibrillar matrix on which the UV-shielding pigment melanin is deposited.1-2

特异性

Anti-PMEL antibody specifically recognizes human PMEL protein.

应用

The antibody may be used in various immunochemical techniques including Immunoblotting (~100 kDa), Immunohistochemistry and Immunofluorescence.
Detection of the PMEL band by Immunoblotting is specifically inhibited by the immunogen.

生化/生理作用

PMEL fibrils are a major functional component of the melanosomal compartment as they optimize melanin polymerization, condensation and storage.1,3
PMEL fibrils have an amyloidogenic nature and share features with pathological amyloids.4 Mutations in PMEL are associated with pigmentation disorders and/or impairments in eye development in various species.1,5,6
PMEL is suggested an excellent model system to study mechanisms of intracellular amyloid formation.1

外形

Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.

储存及稳定性

For continuous use, store at 2-8℃ for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

免责声明

Unless otherwise stated in our catalog  our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

产品性质

抗体形式affinity isolated antibody
质量水平200
形式liquid
species reactivityhuman
浓度~1 mg/mL
technique(s)immunoblotting: 1:1000-1:2000 using human melanoma SK-MEL-28 cell lysate
UniProt登记号P40967
运输dry ice
储存温度−20℃

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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