产品说明
一般描述
Rho guanine nucleotide exchange factor 17 (ARHGEF17), also known as tumor endothelial marker 4 (TEM4) and p164-RhoGEF (Rho-specific guanine-nucleotide exchange factor), encodes a guanine nucleotide exchange factor (GEF) for RhoA GTPases. The encoded protein consists of 1510 amino acids and contains a RhoGEF-specific Dbl homology (DH) domain. It does not contain the typical pleckstrin homology domain. TEM4 is predominantly expressed in the heart. Overexpression of this protein inhibits the transcription of M3 muscarinic receptor-induced genes. TEM4 modulates endothelial cell migration.
免疫原
TEM4 antibody was raised against a 18 amino acid peptide near the center of human TEM4.
特点和优势
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联系
The action of this antibody can be blocked using blocking peptide SBP3500457.
外形
Supplied in PBS with 0.02% sodium azide.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | predicted mol wt 220 kDa |
| species reactivity | human |
| technique(s) | immunofluorescence: suitable immunohistochemistry: suitable indirect ELISA: suitable western blot: suitable |
| NCBI登记号 | Q96PE2 |
| UniProt登记号 | Q96PE2 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... ARHGEF17(9828) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
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