Anti-VISA (AB1) antibody produced in rabbit

产品说明

一般描述

VISA (virus-induced signalling adaptor) is also designated as MAVS (mitochondrial antiviral signalling protein). It has 540 amino acids and three main domains such as N-terminal caspase recruitment and activation domain (CARD), an internal proline-rich region and a C-terminal transmembrane (TM) domain. It is mapped to chromosome 20p13. It is intermediately expressed in all tissues and brain regions except in fetal brain.

免疫原

a 13 amino acid peptide from near the amino-terminus of human VISA.

生化/生理作用

VISA (virus-induced signalling adaptor) serves as an adaptor molecule for retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs). It activates intracellular signaling cascades, that leads to nuclear translocation of the transcription factors- IRF3 (interferon regulatory factor 3), IRF7 (interferon regulatory factor 7), and NF-κB (Nuclear factor-κB). It also helps in the formation of type I interferons (IFN-I) and proinflammatory cytokines.

联系

The action of this antibody can be blocked using blocking peptide SBP4053.

外形

Solution in phosphate buffered saline containing 0.02% sodium azide

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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