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Anti-WDR77 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB1401818
规格纯度
whole antiserum, buffered aqueous solution
参考价格
5045.46 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-WDR77 antibody produced in rabbit
HKMT1069
Nbla10071
MGC2722
MEP50
p44
RP11-552M11.3
产品介绍:

产品说明

一般描述

WDR77 is a component of the 20S PRMT5 (MIM 604045)-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins (see MIM 601061). This modification targets Sm proteins to the survival of motor neurons (SMN) complex (see MIM 600354) for assembly into small nuclear ribonucleoprotein core particles (Friesen et al., 2002 [PubMed 11756452]).[supplied by OMIM

免疫原

WDR77 (NP_077007.1, 1 a.a. ~ 342 a.a) full-length human protein.

Sequence
MRKETPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVVHHVVPTEPLPAPGPASVTE

生化/生理作用

WD repeat domain 77 (WDR77) associates with protein arginine methyltransferase 5 (PRMT5) in a methylosome complex and stimulates its histone methyltransferase activity. It also binds to androgen receptors and modulates its target genes in prostate epithelial cells and prostate cancer.

外形

Clear solution

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式whole antiserum
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
species reactivityhuman
technique(s)western blot: 1:500-1:1000
NCBI登记号NM_024102.2
UniProt登记号Q9BQA1
运输dry ice
储存温度−20℃
Gene Informationhuman ... WDR77(79084)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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