Anti-WNK1 (C-term) antibody produced in rabbit

产品说明

一般描述

The WNK1 gene encodes a cytoplasmic serine-threonine kinase expressed in distal nephron.[supplied by OMIM]
WNK1 (WNK lysine deficient protein kinase 1) gene is mapped to human chromosome 12p13.33. The gene is ubiquitously expressed. The encoded protein contain an active PY motif of short linear proline sequence.

免疫原

WNK1 (Q9H4A3, 2266-2302)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human WNK1.

生化/生理作用

WNK is known to influence the activity of chloride transporters such as members of the SLC12 family. WNK1 regulates ion transportation in kidney and maintains chloride concentration in the neurons. It maintains cell volume during the change in the solute concentration. Osmotic stress and chloride depletion within the cell upregulates WNK1 (WNK lysine deficient protein kinase 1) expression. Mutations in WNK1 leads to familial hyperkalemic hypertension, a Mendelian disorder characterized with thiazide-sensitive hypertension, hyperkalemia, and normal glomerular filtration rate. It is associated with hereditary syndromes like renal disease pseudohypoaldosteronism type II (PHAII) and the neurological disease hereditary sensory neuropathy 2.

外形

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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