产品说明
一般描述
CD24 is a highly glycosylated protein expressed as glycosyl-phosphatidyl-inositol (GPI) anchored molecule. Widely expressed, mainly on T cells, B cells and is upregulated in numerous types of cancers. It has costimulatory activity for antigen specific T cell responses. Polymorphisms of human CD24 are associated with several autoimmune diseases. Recently a new role as negative regulator of the immune response has been reported. CD24-deficient mice are more sensitive to inflammatory responses. CD24 together with the membrane protein SIGLEC interacts with danger-associated molecular patterns (DAMPs), such as HMGB1, HSP90 or HSP70. CD24/SIGLEC complex may differentially regulate the host response to DAMPs and PAMPs (pathogen-associated molecular patterns).
外形
Lyophilized from PBS.
重悬
Reconstitute with 50 μL deionized water.
其他说明
Mouse CD24 (aa 27-52) is fused at the C-terminus to the Fc portion of human IgG1.
基本信息
| NACRES | NA.32 |
产品性质
| 生物来源 | mouse |
| 重组 | expressed in HEK 293 cells |
| 测定 | >90% (SDS-PAGE) |
| 形式 | lyophilized |
| 分子量 | ~50 kDa by SDS-PAGE |
| 包装 | pkg of 50 μg |
| 杂质 | <0.06 EU/μg endotoxin, tested |
| UniProt登记号 | P24807 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | mouse ... CD24(100133941) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
