Fosaprepitant dimeglumine

产品名称：

265121-04-8
Fosaprepitant dimeglumine
[3-{[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl] ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl}-5-oxo- 2H-1,2,4-triazol-1-yl]phosphonic acid
1-Deoxy-1(methylamino)-D-glucitol[3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonate (2:1) (salt)
L-758,298
MK-0517

产品介绍：

产品说明

生化/生理作用

Fosaprepitant dimeglumine acts as a therapeutic agent to treat chemotherapy-induced nausea and vomiting. It also acts as a weak inhibitor of cytochrome P450 3A4 (CYP3A4).
Fosaprepitant dimeglumine is a Substance P/neurokinin-1 (NK1) receptor antagonist. It is a water soluble prodrug of the antiemetic drug aprepitant.

基本信息

经验(实验)分子式	C₂₃H₂₂F₇N₄O₆P · C₁₄H₃₄N₂O₁₀
分子量	1004.83
NACRES	NA.77

产品性质

测定	≥98% (HPLC)
形式	powder
旋光性	[α]/D +27 to +34°, c = 0.5 in methanol
储存条件	desiccated
颜色	white to beige
溶解性	H₂O: 2 mg/mL, clear
运输	wet ice
储存温度	−20℃
SMILES string	FC1=CC=C([C@@H]2N(CCO[C@@H]2O[C@@H](C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C)CC(NC4=O)=NN4P(O)(O)=O)C=C1.CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable