[rel-(1R,2R)-1,2-cyclobutanedimethanamine-κN,kN′][(2S)-2-(hydroxy-kO)propanoato(2-)-kO]-, (SP-4-3)-platinum

产品名称：

135558-11-1
Lobaplatin
[rel-(1R,2R)-1,2-cyclobutanedimethanamine-κN,kN′][(2S)-2-(hydroxy-kO)propanoato(2-)-kO]-, (SP-4-3)-platinum
Cis-[trans-1,2-cyclobutanebis(methylamine)-N,N′]-[(2S)-lactate-O1,O2)-platinum (II)
D19466
trans-1,2-Cyclobutanedimethanamine, platinum complex
D 19466
D-19466

产品介绍：

产品说明

生化/生理作用

Lobaplatin (D-19466) is a third-generation platinum anticancer agent in vitro and in vivo, consisting of ~50:50 mixture of the two trans-1,2-cyclobutanedimethanamine diastereomers in complex with L-lactic acid. Llobaplatin shows antitumor efficacy against various human cancer cancer xenografts and significantly prolongs the survival of mice bearing P388 leukemia (mean life span increase post single i.p. in mg/kg = 46%/4.64 & 77/14.7). Compared to first and second generation platinum compounds, lobaplatin appears to be more stable, less toxic, have a better therapeutic index and may overcome tumor resistance.

基本信息

经验(实验)分子式	C₉H₁₈N₂O₃Pt
分子量	397.33

产品性质

质量水平	100
测定	≥98% (NMR)
形式	powder
颜色	white to beige
溶解性	H₂O: 2 mg/mL, clear (Warmed)
储存温度	−20℃