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Monoclonal Anti-EndoG antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB3500468
规格纯度
clone 7G1C10, purified immunoglobulin, buffered aqueous solution
参考价格
5045.46 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
Monoclonal Anti-EndoG antibody produced in mouse
Anti-Endonuclease G
产品介绍:

产品说明

一般描述

ENDOG (Endonuclease G) is a 28kDa mitochondria-localized protein mapped to human chromosome 9q34.1. However, in presence of certain conditions it can translocate to the nucleus through the BNIP3 (Bcl-2/adenovirus E1B 19kDa protein-interacting protein 3) cell death pathway.

免疫原

Mouse monoclonal EndoG antibody was raised against a recombinant protein corresponding to amino acids 51 – 140 of human EndoG.

应用

Monoclonal Anti-EndoG antibody produced in mouse is suitable for indirect ELISA and western blot.

生化/生理作用

ENDOG (Endonuclease G) is a mitochondrial apoptotic DNase involved in the BNIP3 (Bcl-2/adenovirus E1B 19kDa protein-interacting protein 3) cell death pathway. During mitochondrial release and nuclear translocation of EndoG, BNIP3 interacts with the voltage-dependent anion channel (VDAC) to facilitate the process in the nucleus, it cleaves chromatin apoptotic DNA without the need of caspase activity. ENDOG causes DNA fragmentation during and after apoptosis. It is linked to cardiac hypertrophy and Parkinson′s disease.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Supplied in PBS with 0.02% sodium azide.

基本信息

MDL编号MFCD04040310
NACRESNA.41

产品性质

质量水平100
生物来源mouse
偶联物unconjugated
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆7G1C10, monoclonal
形式buffered aqueous solution
species reactivityhuman, rat, mouse
technique(s)indirect ELISA: suitable
western blot: suitable
NCBI登记号Q14249
UniProt登记号Q14249
运输dry ice
储存温度−20℃
Gene Informationhuman ... ENDOG(2021)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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