Obatoclax mesylate

产品名称：

803712-79-0
Obatoclax mesylate
2-(2-((3,5-Dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl)-1H-indole, methanesulfonate salt
GX15-070 mesylate

产品介绍：

产品说明

生化/生理作用

Obatoclax (GX15–070) is a BH3 domain-targeting inhibitor against Bcl-2 family anti-apoptotic proteins, including A1/Bfl-1, Bcl-2, Bcl-B, Bcl-w, Bcl-XL, and MCL-1. Obatoclax induces cancer cell apoptosis in cultures (0.05-2 μM) and in vivo (1.25-10 mg/kg via im. ip. or iv. in mice) by overcoming Bcl-2 members-mediated resistance to BAX- or BAK-dependent apoptosis.

基本信息

经验(实验)分子式	C₂₀H₁₉N₃O · CH₄O₃S
分子量	413.49
MDL编号	MFCD18074508

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	dark green to black
溶解性	DMSO: 2 mg/mL, clear
储存温度	−20℃
SMILES string	O=S(O)(C)=O.CC1=C(NC(C)=C1)/C=C2N=C(C3=CC4=C(N3)C=CC=C4)C=C\2OC

安全信息

象形图
警示用语：	Danger
危险声明	H301 - H315
预防措施声明	P264 - P270 - P280 - P301 + P310 - P302 + P352 - P332 + P313
危险分类	Acute Tox. 3 Oral - Skin Irrit. 2
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable