产品说明
一般描述
Proprotein convertase subtilisin/kexin type 9 (PCSK9), is an enzyme which in humans is encoded by the PCSK9 gene. This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).
外形
Sterile filtered through a 0.22 micron filter. Lyophilized from 1 x PBS, pH 7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
重悬
Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 100 μg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 month. For extended storage, it is recommended to store at -20℃.
基本信息
| NACRES | NA.32 |
产品性质
| 生物来源 | mouse |
| 重组 | expressed in HEK 293 cells |
| 标签 | 6-His tagged (N-terminus) |
| 测定 | ≥97% (SDS-PAGE) |
| 形式 | lyophilized powder |
| 分子量 | calculated mol wt 72 kDa observed mol wt 20 kDa (DTT-reduced. Protein migrates due to glycosylation. Gln 35 is the predicted N-terminus .) observed mol wt 64 kDa |
| 包装 | pkg of 20 μg |
| 杂质 | <1 EU/μg endotoxin (LAL test) |
| UniProt登记号 | Q80W65 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | mouse ... PCSK9(100102) |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
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