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PD-L1/CD274/B7-H1 from mouse

品牌
Sigma-Aldrich
货号
SRP6433
规格纯度
recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
参考价格
4095.8 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
PD-L1/CD274/B7-H1 from mouse
PDCD1LG1
PDCD1L1
产品介绍:

产品说明

一般描述

Programmed cell death 1 ligand 1 (PD-L1), which is also known as cluster of differentiation (CD274) or B7 homolog 1 (B7-H1), is a member of the growing B7 family of immune molecules. PD-L1 is a cell surface immunoglobulin with two Ig-like domains within the extracellular region and a short cytoplasmic domain. The protein is highly expressed in the heart, skeletal muscle, placenta and lung and weakly expressed in the thymus, spleen, kidney and liver. PD-L1 is expressed on activated T-cells, B-cells, dendritic cells, keratinocytes and monocytes.

生化/生理作用

Programmed cell death 1 ligand 1 (PD-L1) is involved in the regulation of cellular and humoral immune responses. PD-L1 is up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after lipopolysaccharide (LPS) and interferon-γ (IFNG) activation and up-regulated in B-cells activated by surface Ig cross-linking. PD-L1 is involved in the co-stimulatory signal, essential for T-cell proliferation and production of interleukin-10 (IL10) and IFNG, in an interleukin-2-dependent and a programmed cell death 1 (PDCD1)-independent manner.

外形

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.

重悬

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 month. For extended storage, it is recommended to store at -20℃.

基本信息

NACRESNA.32

产品性质

生物来源mouse
重组expressed in HEK 293 cells
标签6-His tagged (C-terminus)
测定≥95% (SDS-PAGE)
形式lyophilized
分子量calculated mol wt 25.6 kDa
observed mol wt 40-50 kDa (DTT-reduced. Protein migrates due to glycosylation. Phe 19 is the predicted N-terminal.)
包装pkg of 10 and 50 μg
杂质<1 EU/μg (LAL test)
UniProt登记号Q9EP73
运输wet ice
储存温度−20℃
Gene Informationmouse ... CD274(60533)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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