产品说明
一般描述
PHLPP2 or PH domain and leucine rich repeat protein phosphatase 2 is the important regulators of Akt serine-threonine kinases and conventional/novel protein kinase C (PKC) isoforms. PHLPP1 and PHLPP2 differentially regulated AKT signaling by selectively dephosphorylating the hydrophobic motifs of AKT2 or AKT3. PHLPP may act as a tumor suppressor in several types of cancer due to its ability to block growth factor-induced signaling in cancer cells.
外形
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
制备说明
after opening, aliquot into smaller quantities and store at -70 ℃. Avoid repeating handling and multiple freeze/thaw cycles
基本信息
NACRES | NA.32 |
产品性质
生物来源 | human |
重组 | expressed in E. coli |
测定 | ≥70% (SDS-PAGE) |
形式 | buffered aqueous glycerol solution |
分子量 | ~56 kDa |
NCBI登记号 | NM_015020 |
运输 | dry ice |
储存温度 | −70℃ |
Gene Information | human ... PHLPP2(23035) |
安全信息
储存分类代码 | 10 - Combustible liquids |
WGK | WGK 1 |