产品说明
生化/生理作用
Profilin is a protozoan parasite protein. It activates toll-like receptor 11 (TLR11), which is an intracellular receptor localized on the endoplasmic reticulum (ER). TLR11 acts as an innate immune sensor for T. gondii profilin (TgPRF).The 12 membrane-spanning ER-resident protein UNC93B1 directly binds TLR11 and control the activation of dendritic cells in response to profilin (Toxoplasma gondii) and parasitic infection in vivo. TLR12 also has an ability to interact with (TgPRF). TLR12 is adequate for recognizing profilin in plasmacytoid dendritic cells (pDCs), whereas TLR11 and TLR12 are both needed in macrophages and conventional DCs. In contrast to TLR11, TLR12-deficient mice fail to resist T. gondii infection.
外形
Lyophilized from PBS.
重悬
Reconstitute with 100 μL deionized water.
其他说明
Recombinant profilin (Toxoplasma gondii) (aa 1-163).
基本信息
| NACRES | NA.32 |
产品性质
| 生物来源 | Toxoplasma gondii |
| 重组 | expressed in E. coli |
| 测定 | >95% (SDS-PAGE) |
| 形式 | lyophilized |
| 分子量 | ~20 kDa by SDS-PAGE |
| 包装 | pkg of 10 μg |
| 储存条件 | avoid repeated freeze/thaw cycles |
| 杂质 | <0.01 EU/μg endotoxin, tested |
| 颜色 | white |
| UniProt登记号 | Q58NA1 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | Toxoplasma gondii ... PRF(7900190) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
