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Progranulin human

品牌
Sigma-Aldrich
货号
SRP8014
规格纯度
recombinant, expressed in HEK 293 cells, untagged, >95% (SDS-PAGE)
参考价格
4420.56 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Progranulin human
PEPI
Activation-inducible TNF-related ligand
Proepithelin
产品介绍:

产品说明

一般描述

Progranulin (PGRN) is a cysteine-rich protein with 593-amino acids and has a molecular weight of ~68.5kDa. The PGRN gene, with one non-coding exon and 12 coding exons spanning 8kb of genomic DNA, is mapped to human chromosome 17q21. The encoded protein is characterized by seven granulin-like domains, which include 7.5 highly conserved tandem repeats of a rare 12 cysteinyl residues. PGRN is predominantly expressed in rapidly cycling epithelial cells, leukocytes, neurons, and chondrocytes.

生化/生理作用

Progranulin (PGRN) is a widely expressed pluripotent growth factor, which plays a crucial role in various processes such as development, cell cycle progression, cell motility, wound repair and inflammation. Additionally, It is also implicated in early embryogenesis, host defense, cartilage development and degradation. Mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). PGRN expression is associated with the development of various type of cancer such as breast cancer, ovarian carcinoma, and multiple myeloma. Overexpression of PGRN has been observed in neurodegenerative diseases such as microglia of Creutzfeldt-Jacob patients and in spinal cord of amyotrophic lateral sclerosis (ALS) patients.

外形

Lyophilized from 0.2 μm-filtered solution in PBS.

重悬

Reconstitute with 100 μL deionized water.

其他说明

Signal peptide and human progranulin (aa 1-593) is untagged. Reflects the native sequence with no additional aa.

产品性质

生物来源human
重组expressed in HEK 293 cells
偶联物untagged
测定>95% (SDS-PAGE)
形式lyophilized
分子量 ~65 kDa by SDS-PAGE
包装pkg of 10 μg
储存条件avoid repeated freeze/thaw cycles
杂质<0.1 EU/μg endotoxin, tested
颜色 white
UniProt登记号P28799
运输wet ice
储存温度−20℃
Gene Informationhuman ... GRN(2896)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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