SMI-4a

产品名称：

438190-29-5
SMI-4a
(Z)-5-(3-Trifluoromethylbenzylidene)thiazolidine-2,4-dione
(5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione

产品介绍：

产品说明

包装

10, 50 mg in glass bottle

生化/生理作用

SMI-4a is a selective ATP-competitive Pim-1 kinase inhibitor with an IC₅₀ of 21 nM for Pim-1 compared to an IC₅₀ of 100 nM for Pim-2 and with little or no activity against a panel of 50 other kinases tested. SMI-4a has been found to inhibit prostate cancer cell growth and induce G1 phase cell-cycle arrest in precursor T-cell lymphoblastic leukemia/lymphoma cell lines.

基本信息

经验(实验)分子式	C₁₁H₆F₃NO₂S
分子量	273.23
MDL编号	MFCD01152003
PubChem化学物质编号	329825328

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: >10 mg/mL
储存温度	2-8℃
SMILES string	FC(F)(F)c1cccc(\C=C2/SC(=O)NC2=O)c1
InChI	1S/C11H6F3NO2S/c12-11(13,14)7-3-1-2-6(4-7)5-8-9(16)15-10(17)18-8/h1-5H,(H,15,16,17)/b8-5-
InChI key	NGJLOFCOEOHFKQ-YVMONPNESA-N